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Individual episodes of the series contain additional references to the Sherlock Holmes tales.

Shore recalled: "I knew, as soon as I left the room, they would be mocking me relentlessly [for my cluelessness] and I thought that it would be interesting to see a character who actually did that before they left the room." The original idea was for House to use a wheelchair, but Fox rejected this.

Jacobs later expressed her gratitude for the network's insistence that the character be reimagined—putting him on his feet added a crucial physical dimension.

Robert Sean Leonard, who portrays Wilson, said that House and his character—whose name is very similar to Watson's—were originally intended to work together much as Holmes and Watson do; in his view, House's diagnostic team has assumed that aspect of the Watson role.

D.) is an American television medical drama that originally ran on the Fox network for eight seasons, from November 16, 2004 to May 21, 2012. Gregory House (Hugh Laurie), a pain medication-dependent, unconventional, misanthropic medical genius who leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital (PPTH) in New Jersey. Kutner makes an appearance late in season five and then reappears in season 8 episode 22.

The series' premise originated with Paul Attanasio, while David Shore, who is credited as creator, was primarily responsible for the conception of the title character. At the end of the third season, this team disbands. Chase and Cameron continue to appear in different roles at the hospital until early in season six.

The series' executive producers included Shore, Attanasio, Attanasio's business partner Katie Jacobs, and film director Bryan Singer. House often clashes with his fellow physicians, including his own diagnostic team, because many of his hypotheses about patients' illnesses are based on subtle or controversial insights. James Wilson (Robert Sean Leonard), head of the Department of Oncology. Rejoined by Foreman, House gradually selects three new team members: Dr. Cameron then departs the hospital, and Chase returns to the diagnostic team. House was among the top 10 series in the United States from its second through fourth seasons.

His flouting of hospital rules and procedures frequently leads him into conflict with his boss, hospital administrator and Dean of Medicine Dr. During the first three seasons, House's diagnostic team consists of Dr. Thirteen takes a leave of absence for most of season seven, and her position is filled by medical student Martha M. Cuddy and Masters depart before season eight; Foreman becomes the new Dean of Medicine, while Dr. Distributed to 66 countries, House was the most-watched television program in the world in 2008.

The show received numerous awards, including five Primetime Emmy Awards, two Golden Globe Awards, a Peabody Award, and nine People's Choice Awards.

On February 8, 2012, Fox announced that the eighth season, then in progress, would be its last.

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